Medically the review by Alan Carter, Pharm.D. — created by Jennifer Berry — to update on January 26, 2021

Alprazolam (Xanax) is a valuable medication for specific mental health conditions. Xanax starts to job-related quickly, and also it continues to be in the body lengthy after the impacts of one dose have worn off.

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Doctors often prescribe Xanax for generalised anxiety disorder and panic disorder. It is among the most usual medications because that these conditions, and also it belongs to a class of drugs called benzodiazepines, or benzos.

Xanax functions by increasing the effects of gamma-aminobutyric acid in the brain. This is a neurotransmitter that increases feelings the calmness.

This article looks at just how long the results of Xanax last, the timeline because that withdrawal, and also the various determinants that influence this timing. It also describes as soon as Xanax expires and also how come safely dispose of old medication.


How lengthy does Xanax continue to be in the body?

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Share ~ above PinterestPeople will usually an alert the results of Xanax in ~ 1 hour.
Like countless drugs, Xanax remains in the body long after a human stops feeling its effects.

Experts use a measurement called half-life come determine just how long a drug continues to be in the body. A drug’s half-life is the lot of time that it takes for the human body to eliminate half of it.

The half-life the Xanax is 8–16 hrs in a healthy and balanced person, with a average half-life the 11 hours. This is much shorter than that of many other benzodiazepines.

The ax “half-life” have the right to be misleading, however. This is since it takes four to five half-lives for the body to totally eliminate a drug. This means that it may take an median of 44–55 hours, or around 2 days, for Xanax to leave the body.

In one study, researcher reported that they could detect Xanax in a who saliva for up to 2.5 work after your last dose.


When walk Xanax begin to work?

The body absorbs Xanax quickly after a person takes it.

Peak level in the blood occur 1–2 hrs after taking a dose. However, the human being will feeling the effects before levels peak.

One study, which examined the results of Xanax in 14 healthy people, found that participants feel the effects of the medication in under 1 hour, through an typical onset time of 49 minutes.


What affects exactly how Xanax works?

The half-life that Xanax can vary from person to person. Several determinants can influence how quickly the body processes it.

Some factors that may adjust the half-life of Xanax include:

being olderbeing of oriental descentsmokinghaving alcohol usage disorderhaving kidney problemshaving liver problems

All that these determinants can rise the time that it takes for the human body to eliminate Xanax completely.

Which drugs deserve to interfere with handling Xanax?

Some medicines reduce the activity of CYP3A, i m sorry is a liver enzyme the helps process Xanax and also eliminate it from the body. These medications are called CYP3A inhibitors.

Taking a CY3PA inhibitor through Xanax way that the body will certainly take longer to procedure the drug. This can cause Xanax to construct up in the blood and increase the threat of serious side effects.

A human being should only take a CYP3A inhibitor v Xanax if a health care provider recommends it.

The adhering to are some instances of CYP3A inhibitors:

azole antifungal agents, consisting of ketoconazole and also itraconazole, which have the right to treat specific fungal infectionscimetidine, which reduces stomach acid and treats stomach ulcers, gastric reflux, and other digestive problems

It is feasible that Xanax could interact with some various other medications and substances, including:

diltiazemisoniazidgrapefruit juice

Xanax and opioids


Share ~ above PinterestOpioids are obtainable by prescription.

Opioids are prescription pains relievers that block pain signal in the brain. Xanax can interact with opioids, and also the interactions deserve to be severe.

Opioids include:

fentanylmorphinecodeineoxycodonehydrocodone

Taking Xanax and also opioids together can reason a deadly overdose, in addition to serious interactions. This is because both opioids and Xanax slow-moving a who breathing, and combining lock may cause breathing to protect against altogether.

If a person has actually been taking an opioid pains reliever, they must talk through their healthcare provider before taking Xanax. Likewise, anyone acquisition Xanax should speak v a doctor prior to taking an opioid.


People can come to be dependent on Xanax, even if they take it together prescribed. The risk of dependency increases if a person takes a higher dosage for a much longer period.

When a human being stops taking Xanax after your body has become used come receiving it, the absence of the medicine can reason a selection of physical and also mental symptoms. These are referred to as withdrawal symptoms.

Withdrawal symptom for brief acting benzodiazepines such as Xanax may begin 1–2 work after the person’s critical dose. They may last for at least 2–4 weeks.

However, in 10–25% of long-term benzodiazepine users, withdrawal symptoms may last because that 12 month or longer. This is dubbed protracted withdrawal.

Xanax withdrawal deserve to be dangerous. Symptoms of tap the money include:

sweatingsensitivity to irradiate or soundmuscle twitchingmuscle crampsblurred visiondifficulty reasoning or concentratinganxietyseizures, including tonic-clonic seizures

A physician can assist a person progressively reduce your Xanax dosage. This is called tapering. Tapering have the right to minimize the threat of severe withdrawal symptoms, consisting of seizures.

Although withdrawal have the right to be difficult, tapering is regularly effective. 2 trials have presented that 71–93% of human being were able to totally stop acquisition Xanax within 8 main by adhering to a doctor-directed tapering schedule.


A bottle of Xanax should carry an expiration date and the date that the pharmacist to fill the prescription.

Expiration days indicate just how long the drug is safe and also effective come take. This day is based on when the manufacturer make the drug.

Taking one expired drug might no longer provide full benefits. Also, there is second risk of adverse effects.

Storing Xanax properly helps ensure the the drug will certainly remain efficient until that is expiration date. Keep it in a dry place at room temperature, i beg your pardon is about 68–77°F (20–25°C).

Do not store Xanax in a bathroom, as moisture and also humidity can cause the medication to malfunction sooner. Also, keep the party out of straight sunlight and also out the the with of children and also pets. Make certain it remains in its initial container.

Disposing of expired Xanax


Share ~ above PinterestStore Xanax in a dry location at room temperature.

If Xanax has expired, it may not be effective or safe. Perform not take expired Xanax before consulting a medical care provider.

Because Xanax tote a high threat of dependency, it is crucial to dispose that expired or unwanted pills correctly.

In the joined States, exactly disposal means taking the medication to one authorized medicine Enforcement management (DEA) controlled substances handle location. A human can uncover a neighborhood location using the DEA’s digital system. Over there are additionally drug take-back job at select times the the year.

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If a person cannot drop off their expired medication at an authorized location, they should follow the indict for safe disposal in the trash from the Food and Drug administration (FDA).